1. Estrogen

a) It is produced in corpus luteum.b) It is responsible for secretory changes in endometrium.c) It is mainly secreted as E3 by the ovary.d) Can not be detected in the blood of postmenopausal.e) Stimulates sebaceous gland activityCorrect Answer: a) It is produced in corpus luteum. It is mainly secreted as E2 by the ovary. It is responsible for proliferative changes in endometrium. Large amounts of estrogens administered systemically can both reduce the size and inhibit sebaceous gland secretion in both sexes.

2. Estrogen is produced from all of the following organs EXCEPT:

a) Corpus luteum.b) Anterior pituitary.c) Placenta.d) Testes.e) Adrenal glands.Correct Answer: b) Anterior pituitary. Estrogens, in females, are produced primarily by the ovaries, and during pregnancy, the placenta. FSH stimulates the ovarian production of estrogens by the granulosa cells of the ovarian follicles and corpora lutea. Some estrogens are also produced in smaller amounts by other tissues such as the liver, adrenal glands, and the breasts. These secondary sources of estrogens are especially important in postmenopausal women. Fat cells produce estrogen as well.

3. Estrogens commonly used in oral contraceptive pills include.

Correct Answer: a) Ethinyl estradiol. EE is an orally bioactive estrogen used in many formulations of combined oral contraceptive pills. It is one of the most commonly used medications for this purpose. While E2 is readily absorbed when taken orally, it is also quickly inactivated by the liver. Substitution at C17 of the estrane steroid with an ethinyl group served to provide an estrogen that is much more resistant to degradation. 

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